Permeability mapping of gelatin methacryloyl hydrogels

Miri A. K., Hosseinabadi H. G., Cecen B., Hassan S., Zhang Y. S.

ACTA BIOMATERIALIA, cilt.77, ss.38-47, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.actbio.2018.07.006
  • Dergi Adı: ACTA BIOMATERIALIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.38-47
  • Anahtar Kelimeler: Gelatin methacryloyl (GelMA), Permeability, Indentation, Photocrosslinking, Drug release
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

We report the development of an efficient, customized spherical indentation-based testing method to systematically estimate the hydraulic permeability of gelatin methacryloyl (GelMA) hydrogels fabricated in a wide range of mass concentrations and photocrosslinking conditions. Numerical simulations and Biot's theory of poroelasticity were implemented to calibrate our experimental data. We correlated elastic moduli and permeability coefficients with different GelMA concentrations and crosslinking densities. Our model could also predict drug release rates from the GelMA hydrogels and diffusion of biomolecules into the three-dimensional GelMA hydrogels. The results potentially provide a design map for choosing desired GelMA-based hydrogels for use in drug delivery, tissue engineering, and regenerative medicine, which may be further expanded to predicting the permeability behaviors of various other hydrogel types.