Practical Approaches to the Determination of the Sample Size in Clinical Studies

DEMİREL N., GÜRLER S.

KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.16, no.2, pp.205-211, 2010 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 2
  • Publication Date: 2010
  • Journal Name: KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.205-211
  • Keywords: Sample size, Randomized controlled trial, Statistical data analysis
  • Dokuz Eylül University Affiliated: Yes

Abstract

The problem of sample size determination is an important and generally difficult step of planning the statistical part of a clinical study. In this paper, some suggestions are made for determining the sample size in a successful and meaningful way. In order to design a high-quality clinical study with reliable results, practical tables and guiding clues are presented for sample size determination of t-tests for paired and independent samples.