Effect of chemotherapy on pulmonary epithelial permeability in lung cancer

Sayit E., Aktogu S., Ertay T., Capa G., Erkmen G., Ozbilek E., ...Daha Fazla

NUCLEAR MEDICINE AND BIOLOGY, cilt.27, sa.6, ss.581-585, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1016/s0969-8051(00)00133-5
  • Dergi Adı: NUCLEAR MEDICINE AND BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.581-585
  • Anahtar Kelimeler: lung cancer, chemotherapy, Tc-99-DTPA inhalation scintigraphy, TRACHEOBRONCHIAL CLEARANCE, MUCOCILIARY CLEARANCE, TOXICITY, BLEOMYCIN, DISEASE, AGENTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The aim of this study is to investigate the effect of one course chemotherapy on the pulmonary epithelial permeability. Eighteen patients (18 male; mean age: 59 +/- 10 years) with lung cancer (11 non-small cell, 7 small cell) inhaled 40 mCi (1,480 MBq) Tc-99m-diethylenetriaminepentaacetic acid (DTPA). Thirty images of 1-min duration were acquired from posterior projection. The first 7 min of the decay corrected time activity curves were used to calculate lung clearance half time. Clearance half times of Tc-99m-DTPA from the peripheral regions of the lungs were 42 +/- 19 min before and 56 +/- 34 min after chemotherapy (p = 0.009); from the central regions, clearance half-times were 112 +/- 94 min before and 160 +/- 125 min after chemotherapy (P = 0.005). This decrease in clearance rate might be related to decreasing mucociliary clearance rate due to the toxic effect of the chemotherapy regimen on cilia movement and/or mucus structure. Tc-99m DTPA radioaerosol study can be used to monitor the toxic effects of chemotherapy on the pulmonary epithelium and possibly on mucociliary function. NUCL MED BIOL 27;6:581-585, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.