Chitosan/montmorillonite composites as matrices for prolonged delivery of some novel nitric oxide donor compounds based on theophylline and paracetamol

Cojocariu A., Porfire L., YILMAZ C. N., Vasile C.

Cellulose Chemistry and Technology, vol.46, no.1-2, pp.35-43, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 1-2
  • Publication Date: 2012
  • Journal Name: Cellulose Chemistry and Technology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.35-43
  • Keywords: Chitosan, Drug release, Kinetics, Montmorillonite, NO-donor drugs, Paracetamol, Theophylline
  • Dokuz Eylül University Affiliated: No


Chitosan-montmorillonite nanocomposite hydrogels were prepared by crosslinking chitosan nanocomposites with glutaraldehyde. The following types of clays have been used: Cloisite 15 A, Cloisite 93 A, Dellite HPS and Dellite 67G. The swelling behaviour of the crosslinked hydrogels containing nanoparticles was followed in acidic media with pH = 2.2. These hydrogels have been loaded with paracetamol, theophylline, two xanthine derivatives 7-[2-hydroxy-3-(4acethyl-amino-phenoxy)-propyl]-8-R-1, 3-dimethyl-xanthine derivatives (with R=H and NO 2 for D 1 and respectively D 2) and two corresponding new nitric oxide donors (NO-donors) as 7-[2-nitroxyacethyl-oxy-3-(4-acethyl-aminophenoxy)-propyl]-8-R-1, 3-dimethy1-xanthine compounds (R=H, NO 2 for 65 and respectively 77 compounds), their controlled release being also evaluated in an acidic solution (pH = 2.2) simulating gastric fluid. The swelling and release kinetics was studied. It has been established that almost all releases involve a non-Fickian or an anomalous transport mechanism.