Beneficial effects of pentoxifylline pretreatment in non-heart-beating donors in rats


Astarcioglu H., Karademir S., ÜNEK T., Ozer E., Menekay S., Coker A., ...More

TRANSPLANTATION, vol.69, no.1, pp.93-98, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 1
  • Publication Date: 2000
  • Doi Number: 10.1097/00007890-200001150-00017
  • Journal Name: TRANSPLANTATION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.93-98
  • Dokuz Eylül University Affiliated: No

Abstract

Background, Pentoxifylline (PTX) pretreatment of recipients was shown to protect against liver graft failure from ischemia-reperfusion injury after orthotopic rat liver transplantation. It has also been shown that PTX protects against normothermic ischemia-reperfusion injury to the liver in lobar ischemia model in the rat. Whether PTX can benefit the liver procured from non-heart-beating donors (NHBDs) with up to 9 hr of cold ischemia is unknown.