Erythrocyte membrane ATPase activities in patients with chronic active hepatitis B and C virus infections

Kuralay F., Tanyalcin T., Ersoz G., Yuce G., Kutay F.

HEPATOLOGY RESEARCH, vol.13, no.3, pp.232-239, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 3
  • Publication Date: 1999
  • Doi Number: 10.1016/s1386-6346(98)00096-5
  • Journal Name: HEPATOLOGY RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.232-239
  • Keywords: erythrocyte membrane, Na+,K+ ATPase, Mg2+ ATPase, Ca2+ ATPase, chronic active hepatitis B, chronic active hepatitis C, liver histopathology, CCL4-INDUCED LIVER-CIRRHOSIS, LIPID-COMPOSITION, PLASMA-MEMBRANES, RAT-LIVER, SILYMARIN, PREVENTION, DIAGNOSIS, DISEASE
  • Dokuz Eylül University Affiliated: No

Abstract

The aim of the present study was to obtain erythrocyte membrane fractions from patients with chronic active hepatitis caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. Na+,K+ ATPase activities were significantly lower (P < 0.005) in HBV related chronic active hepatitis (n = 20, 0.134 +/- 0.073 mu mol P/mg protein per h) and in HCV hepatitis (n = 11, 0.144 +/- 0.049 mu mol P/mg protein per h) when compared to control group (n = 10, 0.219 +/- 0.055 mu mol P/mg protein per h). Both types of chronic active hepatitis B and C have markedly altered erythrocyte membrane Na+,K+ ATPase activities that can be indicative of hepatic cell damage in humans. Although HBV and HCV infections are based on diverse mechanisms of action on their effect in liver injury, they cause similar effects on membrane ATPase activities. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.