The role of cancer stem cells in immunotherapy for bladder cancer: An in vitro study

Ozcan Y., Caglar F., ÇELİK S., Demir A. B., ERÇETİN A. P., Altun Z. S., ...Daha Fazla

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.38, sa.5, ss.476-487, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.urolonc.2020.02.021
  • Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.476-487
  • Anahtar Kelimeler: Bladder cancer, Bacillus Calmette Guerin (BCG), Cancer stem cells (CSCs), In vitro cell lines, EXPRESSION, CLONING, NEUTROPHILS, SEQUENCE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: Bladder cancer is characterized by frequent recurrence and progression. CD44+ cancer stem cells (CSCs) might be one of the main reasons for recurrence. Although Bacillus Calmette Guerin (BCG) has become a gold standard immunotherapy, after treatment recurrence frequently occur. Based on this knowledge, the aim of this study was to evaluate the changes in cytokine and chemokine expressions in bladder cancer and CSCs cultures in vitro with BCG only and in combination with IL2 and lymphocyte (MNCs) applications.