The role of cancer stem cells in immunotherapy for bladder cancer: An in vitro study

Ozcan Y., Caglar F., ÇELİK S., Demir A. B., ERÇETİN A. P., Altun Z. S., ...More

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, vol.38, no.5, pp.476-487, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.1016/j.urolonc.2020.02.021
  • Journal Name: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.476-487
  • Keywords: Bladder cancer, Bacillus Calmette Guerin (BCG), Cancer stem cells (CSCs), In vitro cell lines, EXPRESSION, CLONING, NEUTROPHILS, SEQUENCE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Bladder cancer is characterized by frequent recurrence and progression. CD44+ cancer stem cells (CSCs) might be one of the main reasons for recurrence. Although Bacillus Calmette Guerin (BCG) has become a gold standard immunotherapy, after treatment recurrence frequently occur. Based on this knowledge, the aim of this study was to evaluate the changes in cytokine and chemokine expressions in bladder cancer and CSCs cultures in vitro with BCG only and in combination with IL2 and lymphocyte (MNCs) applications.