The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells

REEL B., Korkmaz C. G., ARUN M. Z., Yildirim G., Ogut D., KAYMAK A., ...More

JOURNAL OF CANCER, vol.6, no.10, pp.1020-1029, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 10
  • Publication Date: 2015
  • Doi Number: 10.7150/jca.12733
  • Journal Name: JOURNAL OF CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1020-1029
  • Keywords: Discoidin domain receptor, MMP, cancer, bisphosphonate, zoledronate, cell culture, NITROGEN-CONTAINING BISPHOSPHONATES, PROSTATE-CANCER, BREAST-CANCER, EXTRACELLULAR-MATRIX, PROTECTIVE ROLE, ACID, INHIBITION, INVASION, ACTIVATION, MIGRATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Discoidin Domain Receptors (DDR1/DDR2) are tyrosine kinase receptors which are activated by collagen. DDR signalling regulates cell migration, proliferation, apoptosis and matrix metalloproteinase (MMP) production. MMPs degrade extracellular matrix (ECM) and play essential role in tumor growth, invasion and metastasis. Nitrogen-containing bisphosphonates (N-BPs) which strongly inhibit osteoclastic activity are commonly used for osteoporosis treatment. They also have MMP inhibitory effect. In this study, we aimed to investigate the effects of zoledronate in PC3 cells and the possible role of DDR signalling and downstream pathways in these inhibitory effects.