The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells

REEL B., Korkmaz C. G., ARUN M. Z., Yildirim G., Ogut D., KAYMAK A., ...Daha Fazla

JOURNAL OF CANCER, cilt.6, sa.10, ss.1020-1029, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.7150/jca.12733
  • Dergi Adı: JOURNAL OF CANCER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1020-1029
  • Anahtar Kelimeler: Discoidin domain receptor, MMP, cancer, bisphosphonate, zoledronate, cell culture, NITROGEN-CONTAINING BISPHOSPHONATES, PROSTATE-CANCER, BREAST-CANCER, EXTRACELLULAR-MATRIX, PROTECTIVE ROLE, ACID, INHIBITION, INVASION, ACTIVATION, MIGRATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Discoidin Domain Receptors (DDR1/DDR2) are tyrosine kinase receptors which are activated by collagen. DDR signalling regulates cell migration, proliferation, apoptosis and matrix metalloproteinase (MMP) production. MMPs degrade extracellular matrix (ECM) and play essential role in tumor growth, invasion and metastasis. Nitrogen-containing bisphosphonates (N-BPs) which strongly inhibit osteoclastic activity are commonly used for osteoporosis treatment. They also have MMP inhibitory effect. In this study, we aimed to investigate the effects of zoledronate in PC3 cells and the possible role of DDR signalling and downstream pathways in these inhibitory effects.