SERUM FERRITIN - A TUMOR-MARKER FOR RENAL-CELL CARCINOMA

ESEN A. A., OZEN H., AYHAN A., ERGEN A., TASAR C., REMZI F.

JOURNAL OF UROLOGY, vol.145, no.6, pp.1134-1137, 1991 (SCI-Expanded, Scopus) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 145 Issue: 6
  • Publication Date: 1991
  • Doi Number: 10.1016/s0022-5347(17)38555-5
  • Journal Name: JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1134-1137
  • Keywords: CARCINOMA, RENAL CELL, TUMOR MARKERS, BIOLOGICAL, FERRITIN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Serum ferritin levels in 32 patients with renal cell carcinoma were evaluated preoperatively and postoperatively. Serum ferritin concentration was significantly higher in renal cell carcinoma patients compared to controls (259.10 versus 61.30 ng./ml., p < 0.001). Furthermore, there was a steady and statistically significant increase in serum ferritin levels with advancing disease stage, as well as a significant decrease in serum ferritin levels after nephrectomy for stages 1 and 2 disease. The intracellular content of ferritin as estimated by polyclonal antibody was dramatically increased in renal cancer tissue compared to normal parenchyma. Although serum ferritin regulation is complex and only partly understood, the present study suggests that serum ferritin may be a useful tumor marker for renal cell carcinoma.