Rhabdomyolysis Associated With Olanzapine Treatment in a Child With Autism
PEDIATRIC EMERGENCY CARE, cilt.26, sa.1, ss.41-42, 2010 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 1
- Basım Tarihi: 2010
- Doi Numarası: 10.1097/pec.0b013e3181c39a22
- Dergi Adı: PEDIATRIC EMERGENCY CARE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.41-42
- Anahtar Kelimeler: autism, rhabdomyolysis, olanzapine
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Children with autism often display difficult behaviors including tantrums, extreme irritability; and physical aggression. There is emerging evidence that olanzapine is useful in decreasing these disruptive behaviors. The most common adverse effects are weight gain and short-term sedation. On the other hand, olanzapine rarely causes rhabdomyolysis. We report a case with rhabdomyolysis in an autistic child just after 2 doses of olanzapine treatment. Initial creatine kinase value was 30,690 IU/L (range, 5-130 U/L), and rhabdomyolysis resolved with hydration and alkalinization over 7 days. Monitoring serum creatine kinase levels may be useful in pediatric cases after initiation of olanzapine treatment.