The short-term effects of intranasal steroids on intraocular pressure in pediatric population

ÖZTÜRK A. T., Engin C. D., KÖKSALDI S., ARIKAN G.

INTERNATIONAL OPHTHALMOLOGY, cilt.42, sa.12, ss.3821-3827, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 12
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10792-022-02402-6
  • Dergi Adı: INTERNATIONAL OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3821-3827
  • Anahtar Kelimeler: Intraocular pressure, Intranasal steroid, Mometasone furoate, Pediatric glaucoma, OCULAR-HYPERTENSIVE RESPONSE, TOPICAL STEROIDS, INDUCED GLAUCOMA, ALLERGIC RHINITIS, CHILDREN, GLUCOCORTICOIDS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose To evaluate the effect of intranasal mometasone furoate (INMF) on short-term intraocular pressure (IOP) alterations in children with allergic rhinitis (AR). Methods Children diagnosed with AR and to whom INMF nasal spray had been firstly prescribed were enrolled. Cases with any ocular diseases except for refractive errors were excluded. Complete ophthalmologic examinations including IOP measurements using Tonopen XL were performed before the treatment as well as at the first and sixth weeks of follow-up. Demographics and ophthalmologic findings were noted and statistically analyzed. Results Study population consisted of 62 right eyes of 62 children with a mean age of 8.55 +/- 3.14 years. Of them, 29 were female (46.8%) and 33 were male (53.2%). Dilated fundoscopy revealed an enlarged Cup/Disc ratio in 12 eyes (19.4%). Family history of glaucoma was positive in 13 cases (21.0%). Mean best corrected visual acuity was found as 0.05 +/- 0.08 logMAR. Initial IOP was 17.1 +/- 2.3 mmHg; whereas it was measured as 18.2 +/- 2.0 mmHg and 17.3 +/- 2.1 mmHg at the first and sixth weeks of follow-up, respectively (p < 0.001). Both at the first and sixth weeks of follow-up, significant IOP rise was present in children with a positive family history of glaucoma (p < 0.001 and p = 0.003, respectively). Besides, increased IOP was found in participants with cupping revealed on fundoscopy at the first week of follow-up (p = 0.044). Conclusion Since children have greater risk for steroid-induced ocular hypertensive response than adults, ophthalmologic evaluation must be recommended in children receiving intranasal steroids.