Prognostic parameters in astrocytoma: p53 and c-erbB-2 immunoreactivity, PCNA, and AgNOR count

Koyuncuoglu M., YÜCESOY K., CİNGÖZ S., Canda M., ÇABUK M., AKTAŞ S.

Turkish Neurosurgery, cilt.9, sa.3-4, ss.85-91, 1999 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3-4
  • Basım Tarihi: 1999
  • Dergi Adı: Turkish Neurosurgery
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.85-91
  • Anahtar Kelimeler: AgNOR, Astrocytomas, c-erbB-2, p53, PCNA
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Most adult primary brain tumors are gliomas. These tumors are progressive, tend to recur after treatment, and are usually fatal. Some studies on the behavior of astrocytomas with similar histological features have looked at overexpression of p53 and c-erbB-2 and the immunoreactivity associated with this, at proliferative indices such as PCNA, and at AgNOR count. In this study, we identified a positive relationship between tumor progression and p53 and c-erbB-2 immunoreactivity. PCNA staining and AgNOR counts were higher in cases of tumor recurrence.