Relationship of Systemic Antiinflammatory Markers and Functional Parameters in Chronic Obstructive Pulmonary Disease

Satar S., Alpaydin A., Var A., Coskun A. S., Celik P., Yorgancioglu A.

TURKISH THORACIC JOURNAL, vol.12, no.3, pp.88-93, 2011 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.5152/ttd.2011.21
  • Journal Name: TURKISH THORACIC JOURNAL
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.88-93
  • Keywords: Chronic Obstructive Pulmonary Disease, systemic inflammation, oxidative stress, nitric oxide, malonyl dialdehyde, superoxide dismutase, glutathionperoxidase, NITRIC-OXIDE SYNTHASE, OXIDATIVE STRESS, SKELETAL-MUSCLE, COPD
  • Dokuz Eylül University Affiliated: No

Abstract

Objective: Airway inflammation and oxidative stress biomarkers increase in chronic obstructive pulmonary disease (COPD) and this is thought to be related to faster decrease in lung functions. Systemic markers of oxidative stress include nitric oxide (NO) and malonyl dialdehyde (MDA), while antioxidant markers are erythrocyte superoxide dismutase (SOD) and gluthathion-peroxidase (GSH-Px). We investigated the relationship between levels of systemic oxidative/antioxidant markers and functional parameters.