Immune Checkpoint Inhibitors in Advanced-Stage Non-small Cell Lung Cancer

KAZAZ S. N., ÖZTOP İ.

TURKISH THORACIC JOURNAL, cilt.18, sa.4, ss.101-107, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 18 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/turkthoracj.2017.17006
  • Dergi Adı: TURKISH THORACIC JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.101-107
  • Anahtar Kelimeler: Non-small cell lung cancer, immunotherapy, checkpoint inhibitors, AVELUMAB MSB0010718C, ADVANCED NSCLC, OPEN-LABEL, PHASE 1B, IMMUNOTHERAPY, DOCETAXEL, NIVOLUMAB, BLOCKADE, 1ST-LINE, TRIAL
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

More than half of non-small cell lung cancer (NSCLC) patients are at an advanced stage at the time of diagnosis, and they have a poor prognosis. Systemic treatment is the basic treatment approach for advanced-stage NSCLC, and chemotherapy and targeted treatments are commonly used based on the molecular characteristics. Although targeted therapies have led to a significant level of improvement in terms of survival, the results are still unsatisfactory. However, considerable attention has been focused to the immunotherapy with recent positive results reported by studies on this field. In this context, a certain portion of clinical studies have shown dramatic results, and these have involved inhibitors developed particularly against the immune checkpoint protein programmed death receptor-1 and its ligand (programmed death ligand-1). This review aims to present the significance of immune checkpoint inhibitors in NSCLC and to summarize the findings of relevant contemporary clinical studies.