The effect of atorvastatin on lung histopathology in a murine model of chronic asthma

Firinci F., KARAMAN M., CİLAKER MIÇILI S., BAĞRIYANIK H. A., UZUNER N., KARAMAN Ö.

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.42, sa.4, ss.355-361, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.aller.2013.09.002
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.355-361
  • Anahtar Kelimeler: Asthma, Atorvastatin, Mice, PLATELET-ACTIVATING-FACTOR, AIRWAY INFLAMMATION, ALLERGIC-ASTHMA, IN-VITRO, SMOOTH-MUSCLE, STATINS, SIMVASTATIN, BRONCHOCONSTRICTION, PRAVASTATIN, MECHANISM
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Atorvastatin is a statin group medicine that reduces the level of serum cholesterol; thus it is used to treat hypercholesterolaemia. Independent of the cholesterol-lowering property of statins they also have anti-inflammatory and immunomodulating effects. This study aimed to investigate the effect of atorvastatin on histological changes in the lungs in a murine model of chronic asthma.