Interference in ACTH immunoassay negatively impacts the management of subclinical hypercortisolism.
Endocrine, cilt.56, sa.2, ss.308-316, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 2
- Basım Tarihi: 2017
- Doi Numarası: 10.1007/s12020-017-1268-7
- Dergi Adı: Endocrine
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.308-316
- Anahtar Kelimeler: Corticotropin, Interference, Subclinical Cushing's syndrome
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
Purpose Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions.