Interference in ACTH immunoassay negatively impacts the management of subclinical hypercortisolism.

Yener S., DEMİR L., Demirpence M., BARIŞ M. M., YILDIRIM ŞİMŞİR I., Ozisik S., ...More

Endocrine, vol.56, no.2, pp.308-316, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 56 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.1007/s12020-017-1268-7
  • Journal Name: Endocrine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.308-316
  • Keywords: Corticotropin, Interference, Subclinical Cushing's syndrome, HETEROPHILIC ANTIBODY INTERFERENCE, CUSHINGS-SYNDROME, ADRENAL INCIDENTALOMA, IMMUNORADIOMETRIC ASSAY, MACROPROLACTIN, MULTICENTER, DIAGNOSIS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions.