Interference in ACTH immunoassay negatively impacts the management of subclinical hypercortisolism.

Yener S., DEMİR L., Demirpence M., BARIŞ M. M., YILDIRIM ŞİMŞİR I., Ozisik S., ...Daha Fazla

Endocrine, cilt.56, sa.2, ss.308-316, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s12020-017-1268-7
  • Dergi Adı: Endocrine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.308-316
  • Anahtar Kelimeler: Corticotropin, Interference, Subclinical Cushing's syndrome, HETEROPHILIC ANTIBODY INTERFERENCE, CUSHINGS-SYNDROME, ADRENAL INCIDENTALOMA, IMMUNORADIOMETRIC ASSAY, MACROPROLACTIN, MULTICENTER, DIAGNOSIS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose Low plasma corticotropin is considered a useful parameter for the diagnosis of subclinical hypercortisolism in patients with an adrenal incidentaloma. However, immunoassays are vulnerable to interference from endogenous antibodies. In this study, subjects who underwent Hypothalamus-pituitary-adrenal axis evaluation for the assessment of subclinical hypercortisolism were evaluated. The objective of the study was to ascertain whether antibody interference in corticotropin immunoassay affected the diagnostic work-up and clinical decisions.