Clinical significance of basal core promoter and precore mutations in chronic hepatitis B

Ozgenc O., Ozacar T., Erensoy S., Inan N., Ari A., Kuruuzum Z., ...More

HEPATO-GASTROENTEROLOGY, vol.54, no.80, pp.2319-2323, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 80
  • Publication Date: 2007
  • Journal Name: HEPATO-GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2319-2323
  • Keywords: chronic hepatitis B, basal core, promoter, precore, mutants, E-ANTIGEN SEROCONVERSION, VIRAL REPLICATION, VIRUS GENOTYPES, LAMIVUDINE THERAPY, LIVER-DAMAGE, LONG-TERM, INTERFERON, MUTANTS, PREVALENCE, INFECTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background/Aims: The mutations in the basal core promoter and precore region of hepatitis B virus genome in hepatitis B e antigen-positive and -negative chronic hepatitis B patients have been described. The reports about their prevalence and clinical significance in the Mediterranean region where D is the predominant genotype, are very limited.