Superficial photothermal laser ablation of ex vivo sheep esophagus using a cone-shaped optical fiber tip

TOZBURUN S.

JOURNAL OF BIOPHOTONICS, cilt.13, sa.6, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/jbio.201960116
  • Dergi Adı: JOURNAL OF BIOPHOTONICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Agricultural & Environmental Science Database, BIOSIS, Biotechnology Research Abstracts, Communication Abstracts, Compendex, EMBASE, INSPEC, MEDLINE, Metadex, Civil Engineering Abstracts
  • Anahtar Kelimeler: chemical etching, fiber probe, Monte Carlo, mucosa, photothermal ablation, ENDOSCOPIC MUCOSAL RESECTION, BARRETTS-ESOPHAGUS, RADIOFREQUENCY ABLATION, POPULATION, PREVALENCE, MANAGEMENT, THERAPY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Superficial photothermal laser ablation (SPLA) may be useful as a therapeutic approach producing a depth of injury that is sufficient to eliminate mucosal lesion but not deep enough to induce thermal effects in deeper tissue layers. The purpose of this preliminary study is twofold: (a) to describe design steps of a fiber probe capable of delivering a tightly focused laser beam, including Monte-Carlo-based simulations, and (b) to complete the initial testing of the probe in a sheep esophagus model, ex vivo. The cone-shaped (tapered) fiber tip was obtained by chemical etching of the optical fiber. A 1505 nm diode laser providing power up to 500 mW was operated in continuous wave. The successful SPLA of the sheep mucosa layer was demonstrated for various speed-power combinations, including 300 mW laser power at a surface scanning rate of 0.5 mm/s and 450 mW laser power at a surface scanning rate of 2.0 mm/s. Upon further development, this probe may be useful for endoscopic photothermal laser ablation of the mucosa layer using relatively low laser power.