Serum apelin levels and body composition changes in breast cancer patients treated with an aromatase inhibitor

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Salman T., DEMİR L., Varol U., Akyol M., Oflazoglu U., Yildiz Y., ...More

JOURNAL OF BUON, vol.21, no.6, pp.1419-1424, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 21 Issue: 6
• Publication Date: 2016
• Journal Name: JOURNAL OF BUON
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1419-1424
• Keywords: apelin, postmenopausal breast cancer, aromatase inhibitors, CELL-PROLIFERATION, RECEPTOR, EXPRESSION, OBESITY, APJ, LIGAND, RISK, LOCALIZATION, ADIPOSITY, PROGNOSIS
• Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: The adipose tissue plays a role in carcinogenesis with the adipokines it generates. Apelin is an anti-obesigenic adipokine, and assumes roles in both vascularization and tumor cell proliferation. The present study aimed to investigate changes in apelin levels, in postmenopausal breast cancer (BC) patients receiving aromatase inhibitors (AIs).