Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G

Koseoglu V., Kismet E., Soysal Y., Ulucan H., Dundaroz R., Imirzahoglu N., ...More

PEDIATRICS INTERNATIONAL, vol.46, no.4, pp.415-418, 2004 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1442-200x.2004.01930.x
  • Journal Name: PEDIATRICS INTERNATIONAL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.415-418
  • Keywords: benzathine penicillin G, rheumatic fever, sister chromatid exchange, SYSTEMIC LUPUS-ERYTHEMATOSUS, BETA-LACTAMS, FREQUENCIES, CELLS
  • Dokuz Eylül University Affiliated: No

Abstract

Background: Benzathine penicillin G (BPG) is a widely used antibiotic for treatment or prophylaxis of certain infectious diseases. Previous in vivo studies using sister chromatid exchange (SCE) frequency and comet assay, had showed that long-term administration of benzathine penicillin G may cause some degree of DNA damage in children with rheumatic fever.