Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G

Koseoglu, V; Kismet, E; Soysal, YASEMİN; Ulucan, H; Dundaroz, R; Imirzahoglu, N; Gokcay, E

doi:10.1111/j.1442-200x.2004.01930.x

Investigation of DNA damage in lymphocytes exposed to benzathine penicillin G

Koseoglu V., Kismet E., Soysal Y., Ulucan H., Dundaroz R., Imirzahoglu N., ...Daha Fazla

PEDIATRICS INTERNATIONAL, cilt.46, sa.4, ss.415-418, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 46 Sayı: 4
Basım Tarihi: 2004
Doi Numarası: 10.1111/j.1442-200x.2004.01930.x
Dergi Adı: PEDIATRICS INTERNATIONAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.415-418
Anahtar Kelimeler: benzathine penicillin G, rheumatic fever, sister chromatid exchange
Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Benzathine penicillin G (BPG) is a widely used antibiotic for treatment or prophylaxis of certain infectious diseases. Previous in vivo studies using sister chromatid exchange (SCE) frequency and comet assay, had showed that long-term administration of benzathine penicillin G may cause some degree of DNA damage in children with rheumatic fever.