RENALASE: A POTENTIAL BIOMARKER FOR PRIORITIZING DMSA IN THE TOP-DOWN APPROACH TO VESICOURETERAL REFLUX

Sütçüoğlu N., Olguner M., Ulusoy O., Ateş O., Hakgüder F. G., Akgür M. F.

43. Ulusal Çocuk Cerrahisi kongresi ve Mısır Çocuk Cerrahisi ortak kongresi, İstanbul, Türkiye, 21 - 24 Ekim 2026, ss.128-129, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: İstanbul
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.128-129
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aim:

This study aimed to investigate the relationship between serum renalase levels and the presence of renal scarring in

children who underwent Dimercaptosuccinic Acid (DMSA) renal scintigraphy due to suspected vesicoureteral reflux

(VUR) or a history of febrile urinary tract infection, and to determine whether renalase could serve as a potential

biomarker for predicting renal scarring.

Methods:

This study included a total of 35 patients who underwent DMSA renal scintigraphy and had serum renalase levels

measured. The patients were divided into two groups according to the presence of renal scarring on scintigraphy.

Demographic data, laboratory parameters, presence of vesicoureteral reflux, scarring status, and serum renalase levels

were recorded. Appropriate statistical tests were used for intergroup comparisons. The predictive performance of

renalase for renal scarring was evaluated using Receiver Operating Characteristic (ROC) analysis.

Results:

Median serum renalase levels differed significantly between the renal scar-positive and renal scar-negative groups on

DMSA scintigraphy (p <0.05). In ROC analysis, serum renalase demonstrated a moderate predictive ability for renal

scarring, with an area under the curve (AUC) of approximately 0.75. The optimal serum renalase cutoff value for

predicting scarring was calculated as 44.63 ng/mL. Renalase levels showed no significant correlation with age, sex,

blood urea nitrogen (BUN) or serum creatinine.

Conclusion:

Serum renalase levels may have the potential to predict the presence of renal scarring in children. In patients with

elevated renalase levels, particularly in high-risk groups with abnormal renal ultrasonography findings or a history of

recurrent urinary tract infections, prioritizing DMSA renal scintigraphy may be appropriate for the detection of renal

damage. Further multicenter studies with larger sample sizes are needed to provide more reliable and generalizable

results.