Akademik Veri Yönetim Sistemi
Jinekoloji ve Obstetrik Dergisi, cilt.22, sa.1, ss.20-24, 2008 (Scopus)
OBJECTIVE: The purpose of this study is to consider the effectiveness of Pipelle biopsy and curettage as preoperative endometrial sampling types in delecting endometrial tumors and finding out the accurate histological type and degree, which directly have an impact on patients' survival. This consideration was done by comparing preoperative and postoperative pathological results of patients treated in one medical centre. STUDY DESING: The study group consists ofpatients treated for endometrium cancer between 2003-2007 al Dokuz Eylul University School of Medicine (DEUSM) in Department of Obstetrics and Gynecology. In total 93 preoperative samples and postoperative hysterectomy specimens, of which 78 were obtained through curettage and 15 through Pipelle biopsy, were examined in DEUSM Pathology Department. The Kappa statistic which examines the coherence between the two results was used in order to evaluate the preoperative and hysterectomy findings according to histological type and degree of the tumor. In addition, the sensitivity in detecting tumors, the accuracy of defining histological type and degree was evaluated seperately. RESULTS: In detecting the endometrial malignancy the sensitivity level for curettage was 92.3 % (72/78) and 86.6 % (13/15) for Pipelle biopsy. The concordance between preoperative histologic findings and postoperative pathologic results was 69 of 72 (95.83 %) for curettage and 13 of 13 (100 %) for Pipelle biopsy. Based on the results, the Kappa statistic was calculated as 0.73 for curettage. Although correct histological findings were obtained for all patients with Pipelle biopsy, it was not possible to calculate Kappa statistic for Pipelle biopsy due to the insufficient amount of cases. Preoperative endometrial samples which show concordance in finding out both the histological type and degree, with postoperative pallwlogicalfindings were 46 out of72 (63.88 %) for curettage and 12 out of 13 (92.30 %) for Pipelle biopsy. Kappa statistic was 0.37 for curettage and it could not be calculated for Pipelle biopsy due to insufficient amount of cases. CONCLUSION: Though the aim of the research was to evaluate which preoperative endometrial sampling method is more succesful in attaining correct histological findings and grading in endometrial cancer, due to the retrospective nature of this study, sufficient amount of cases were not available and as a result of this, it was not possible to compare the two methods effectively. Nevertheless, in light of the outcome of the research, the results of preoperative endometrial sampling by curettage on patients with endometrial cancer can be used as a dependable guide by gynocologic oncologists in evaluating preoperative clinical findings and in conducting possible surgical intervention.