The interaction of the diltiazem with oral and intravenous cyclosporine in rats

Kalkan Ş., Gumustekin M., Aygoren O., Tuncok Y., Gelal A., Guven H.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, cilt.29, sa.2, ss.119-123, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1007/bf03190586
  • Dergi Adı: EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.119-123
  • Anahtar Kelimeler: cyclosporine, metabolism, pharmacokinetics, diltiazem, interaction, PHARMACOKINETIC DRUG-INTERACTIONS, RENAL-TRANSPLANT RECIPIENTS, HUMAN-LIVER, METABOLISM, BIOAVAILABILITY, ABSORPTION, IDENTIFICATION, KETOCONAZOLE, INHIBITION, DISPOSITION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

This study investigated the effect of diltiazem on the bioavailability of oral and intravenous cyclosporine (CsA) in rats. While control rats received normal saline, experimental groups received 60 or 90 mg/kg diltiazem orally for 3 days. Each group divided into 2 equal groups that received a single oral dose or i.v. injection of CsA. Pharmacokinetic parameters were analyzed by nonparametric analysis of variance. Pretreatment with 60 or 90mg/kg diltiazem decreased the area under the blood CsA concentration-time curve (AUC) of oral CsA compared to control group (54.5% and 65.5% for AUC(0.24). 57.6% and 62.2% for AUC(0-infinity), respectively, p<0.05).