Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.35, sa.1, ss.31-35, 2015 (SCI-Expanded)
© 2015 by Türkiye Klinikleri.Although importance of expression status of caveolin-1 protein was established in different cancers including the renal cell carcinoma, its significance has not been evaluated in Wilms tumor. The aim of this study was to determine the prognostic value of caveolin-1 in Wilms tumor. Material and Methods: Immunhistochemical caveolin-1 expression was studied in a total of 50 formalin-fixed, paraffin-embedded Wilms tumor specimens and its association with different clinicopathologic parameters was evaluated. Results: Caveolin-1 expression was positive in 24 tumors (48%), while was absent in 26 tumors (52%). Using Mann Whitney U Analysis, Caveolin-1 expression was found to be associated with the weight of the kidney (p=0.013). In addition; there was statistical significance with Caveolin-1 expression and therapy response (p=0.049). But there were no statistical relationships between with Caveolin-1 and some clinical prognosis factors such as stage (p=0.093) and survive (p=0.256). Conclusion: In the present study, it was shown that the presence of caveolin-1 expression in Wilms tumor associated with both tumor size and therapy response. These findings were thought that Caveolin-1 expression may play a role in Wilms tumor evolution.