Meta-analysis of longitudinal studies of cognition in bipolar disorder: comparison with healthy controls and schizophrenia

BORA İ. E., Ozerdem A.

PSYCHOLOGICAL MEDICINE, vol.47, no.16, pp.2753-2766, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 47 Issue: 16
  • Publication Date: 2017
  • Doi Number: 10.1017/s0033291717001490
  • Journal Name: PSYCHOLOGICAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.2753-2766
  • Keywords: Bipolar disorder, cognition, longitudinal, mania, schizophrenia, 5-YEAR FOLLOW-UP, I DISORDER, EUTHYMIC PATIENTS, OLDER-ADULTS, METABOLIC SYNDROME, IMPAIRMENT, PERFORMANCE, DEFICITS, LITHIUM, ONSET
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background Bipolar disorder (BP) is associated with significant cognitive impairment. Recent evidence suggests that cognitive deficits are already evident after first-episode mania. However, it is not clear whether BP is associated with further decline in cognitive functions in individuals with established illness. Aim of this meta-analytic review was to examine longitudinal neurocognitive changes in BP and to compare trajectory of cognitive deficits in BP with schizophrenia and healthy controls.