Epidemiology of paediatric severe sepsis and septic shock in Turkey: Prevalence, results and treatments study

EVREN G., Karaarslan U., Yildizdas D., Sik G., Azapagasi E., KONCA Ç., ...More

ACTA PAEDIATRICA, vol.111, no.10, pp.1995-2003, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 111 Issue: 10
  • Publication Date: 2022
  • Doi Number: 10.1111/apa.16484
  • Journal Name: ACTA PAEDIATRICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Psycinfo, Public Affairs Index, Veterinary Science Database
  • Page Numbers: pp.1995-2003
  • Keywords: intensive care units, mortality, paediatrics, septic shock, severe sepsis, ORGAN DYSFUNCTION SYNDROME, MECHANICAL VENTILATION, MORTALITY, CHILDREN, OUTCOMES, TRENDS, SCORE
  • Dokuz Eylül University Affiliated: Yes


Aim This study was aimed at characterising the prevalence, management and outcomes of paediatric severe sepsis and septic shock in tertiary paediatric intensive care units (PICUs) in Turkey. Methods A point prevalence study was conducted on 5 days over the course of 1 year in 29 PICUs in Turkey. Outcomes included severe sepsis and septic shock point prevalence, therapies used, duration of PICU stay and mortality at day 28. Results Of the 1757 children who were admitted to the PICU during the study period, 141 (8.0%) children met the consensus criteria for severe sepsis and 23 (1.3%) children met the criteria for septic shock. Paediatric severe sepsis and septic shock accounted for 8% and 1.3% of all PICU admissions, respectively. The median age of the patients was 2.6 years (interquartile range [IQR], 0.7-8.6 years). Enteral nutrition (79.3%) was preferred compared to parenteral nutrition (31.1%) for the first 3 days after PICU admission. A total of 39 patients died while in the PICU, for a 23.8% mortality rate, which did not vary by age. Conclusion The mortality rate was similar to that in other studies. Hematologic-immunologic comorbidity, parenteral nutrition and the use of vasoactive drugs were independently associated with mortality.