Atıf İçin Kopyala
Gucluler G., Piskin O., Baran Y.
JOURNAL OF BUON, cilt.16, sa.4, ss.646-651, 2011 (SCI-Expanded)
-
Yayın Türü:
Makale / Tam Makale
-
Cilt numarası:
16
Sayı:
4
-
Basım Tarihi:
2011
-
Dergi Adı:
JOURNAL OF BUON
-
Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
-
Sayfa Sayıları:
ss.646-651
-
Anahtar Kelimeler:
bioactive sphingolipids, breast cancer, glucosylceramide synthase, MCF-7, sphingosine kinase-1, MYELOID-LEUKEMIA CELLS, MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, SYNTHASE, CERAMIDE, EXPRESSION, SPHINGOSINE-1-PHOSPHATE, SPHINGOLIPIDS, MECHANISMS, APOPTOSIS
-
Dokuz Eylül Üniversitesi Adresli:
Evet
Özet
Purpose: Sphingolipids are important signaling molecules mediating cell survival, proliferation, cell cycle regulation and apoptosis. Ceramide is the most vital sphingolipid which induces growth arrest, senescence, and apoptosis. In this study, we aimed to determine the roles of sphingosine kinase-1 (SK-1) and glucosylceramide synthase (GCS) genes in paclitaxel, doxorubicin, tamoxifen, cyclophosphamide and docetaxel induced apoptosis in human MCF-7 breast cancer cells.