The roles of antiapoptotic sphingosine kinase-1 and glucosylceramide genes in drug induced cell death of MCF-7 breast cancer cells


Gucluler G., Piskin O., Baran Y.

JOURNAL OF BUON, vol.16, no.4, pp.646-651, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2011
  • Journal Name: JOURNAL OF BUON
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.646-651
  • Keywords: bioactive sphingolipids, breast cancer, glucosylceramide synthase, MCF-7, sphingosine kinase-1, MYELOID-LEUKEMIA CELLS, MULTIDRUG-RESISTANCE, P-GLYCOPROTEIN, SYNTHASE, CERAMIDE, EXPRESSION, SPHINGOSINE-1-PHOSPHATE, SPHINGOLIPIDS, MECHANISMS, APOPTOSIS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Sphingolipids are important signaling molecules mediating cell survival, proliferation, cell cycle regulation and apoptosis. Ceramide is the most vital sphingolipid which induces growth arrest, senescence, and apoptosis. In this study, we aimed to determine the roles of sphingosine kinase-1 (SK-1) and glucosylceramide synthase (GCS) genes in paclitaxel, doxorubicin, tamoxifen, cyclophosphamide and docetaxel induced apoptosis in human MCF-7 breast cancer cells.