The dosage-dependent prenatal caffeine exposure adversely affects levels of integrin alpha V beta 3 and MMP-9 in a rat model of embryo implantation


Yilmaz F., Tekmen I.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, vol.121, no.9, pp.648-655, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 121 Issue: 9
  • Publication Date: 2020
  • Doi Number: 10.4149/bll_2020_105
  • Journal Name: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Page Numbers: pp.648-655
  • Keywords: caffeine, embryo implantation, integrin, MMP-9, MUCIN 1, PREGNANCY, EXPRESSION, UTERUS
  • Dokuz Eylül University Affiliated: Yes

Abstract

OBJECTIVE: In the pregnancy period, it is recommended to limit the consumption of caffeine. However, the mechanisms of caffeine effect during pregnancy are not fully known. In our study, we aimed to investigate the effect of prenatal caffeine consumption on the embryonic implantation in rats as well as shed light on the relationship between the molecules and implantation stages.