Exploring at the molecular level the effects of blood and blood-insulin cardioplegias used during open-heart surgeries on myocardial prevention

Guzleoglu M., Catalyurek H., Oktay G., ALTUN Z. S., Silistireli E., Sariosmanoglu N., ...More

JOURNAL OF CARDIOVASCULAR SURGERY, vol.49, no.6, pp.809-816, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 6
  • Publication Date: 2008
  • Journal Name: JOURNAL OF CARDIOVASCULAR SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.809-816
  • Keywords: Cardiopulmonary bypass, Heart arrest, induced, Cardiac surgical procedures, SOLUBLE ADHESION MOLECULES, PYRUVATE-DEHYDROGENASE, REPERFUSION, INJURY, STIMULATION, METABOLISM, ACTIVATION, EXPRESSION, RELEASE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim. The aim of this study was to measure the changes in the levels of soluble adhesion molecules involved in acute inflammation during ischemia-reperfusion in adults who underwent open-heart surgery using blood and blood-insulin cardioplegia and to examine the differences in tissue damage at the molecular level as a consequence of insulin's effect on myocardial energy metabolism.