Ischemia/reperfusion injury in flow-through venous flaps.

Atabey A., Gezer S., Vayvada H., Kirkali G., Menderes A., Karaca C., ...More

Annals of plastic surgery, vol.40, no.6, pp.612-6, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 6
  • Publication Date: 1998
  • Doi Number: 10.1097/00000637-199806000-00007
  • Journal Name: Annals of plastic surgery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.612-6
  • Dokuz Eylül University Affiliated: Yes


The effects of ischemia/reperfusion (IIR) injury in flow-through venous flaps were evaluated in rabbits. The rates of flap survival and the levels of lipid peroxidation, protein oxidation, and sulfhydryl groups were compared between flow-through venous flaps, conventional flaps after an IIR period (experimental groups), and flow-through venous flaps without being subjected to IIR injury (control groups) in 20 animals. On the seventh day after the onset of reperfusion, 3 of 10 flow-through venous flaps (30%) and 6 of 10 arteriovenous flaps (60%) survived in the experimental groups. Flow-through venous flaps showed a decreased survival rate compared with control and conventional flaps (p < 0.05). Tissue lipid peroxide levels were found to be higher in venous flaps during reperfusion after secondary ischemia (p < 0.05), Tissue protein oxidation and total sulfhydryl groups levels did not show any difference among groups. This study suggests that more free radical damage occurs in flow-through venous flaps during IIR injury.