Ischemia/reperfusion injury in flow-through venous flaps.
Annals of plastic surgery, cilt.40, sa.6, ss.612-6, 1998 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 6
- Basım Tarihi: 1998
- Doi Numarası: 10.1097/00000637-199806000-00007
- Dergi Adı: Annals of plastic surgery
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.612-6
- Dokuz Eylül Üniversitesi Adresli: Evet
Özet
The effects of ischemia/reperfusion (IIR) injury in flow-through venous flaps were evaluated in rabbits. The rates of flap survival and the levels of lipid peroxidation, protein oxidation, and sulfhydryl groups were compared between flow-through venous flaps, conventional flaps after an IIR period (experimental groups), and flow-through venous flaps without being subjected to IIR injury (control groups) in 20 animals. On the seventh day after the onset of reperfusion, 3 of 10 flow-through venous flaps (30%) and 6 of 10 arteriovenous flaps (60%) survived in the experimental groups. Flow-through venous flaps showed a decreased survival rate compared with control and conventional flaps (p < 0.05). Tissue lipid peroxide levels were found to be higher in venous flaps during reperfusion after secondary ischemia (p < 0.05), Tissue protein oxidation and total sulfhydryl groups levels did not show any difference among groups. This study suggests that more free radical damage occurs in flow-through venous flaps during IIR injury.