Akademik Veri Yönetim Sistemi
Jinekoloji ve Obstetrik Dergisi, cilt.17, sa.1, ss.52-56, 2003 (Scopus)
OBJECTIVE: The purpose of this study was to elevate gonadotrophin levels by using naloxone and also providing menstruation in a woman aged 18 with primary hypothalamic amenorrhea. STUDY DESIGN: In the beginning, 2 mg naloxone was given intravenously (IV) to the subject in five minutes and later 0.5 mg/hr naloxone was applied continuously IV infusion. With this treatment gonadotrophin level was not elevated, then conjugated estrogen was applied for 14 days. After estrogen treatment, the administration of naloxone was repeated. For each 15-minutes-interval, blood samples were taken just before naloxone application, during naloxone infusion and untill the end of the infusion. The sera of collected blood were seperated, LH, FSH, estradiol and PRL levels were measured by using radioimmunoassay. RESULT (s): Before naloxone treatment, serum LH, FSH, Prolactin levels were 0.05 mIU/ml, 1.45 mIU/ml and 6.11 ng/ml respectively, the levels of E2 were under the range. No change in hormone levels was observed with neither only naloxone, nor E2 plus naloxone treatment. All measured FSH and LH levels were under 2 mIU/ml, gonadotrophin levels were not elevated above the prepubertal levels and spontaneous menstruation could not be achieved. CONCLUSION (s): Even after E2 treatment, naloxone failed to elevate serum levels of gonadotrophin in primary hypothalamic amenorhea. The menstration is triggered by factors besides the opioids; and the regulation of FSH, LH, and PRL secretion are not controlled by opioids at the prepubertal period.