Does silymarin combined with cisplatin affect neuroblastoma cell death via pro-inflammatory cytokine production?

ALTUN Z. S., Cecen E., Pamukoglu A., AKTAŞ S., Olgun N.

IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, vol.6, no.1, pp.37-45, 2016 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5222/buchd.2016.037
  • Journal Name: IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.37-45
  • Keywords: Silymarin, neuroblastoma, anti-proliferative, cisplatin, pro-inflammatory cytokines, PROSTATE-CANCER, SILIBININ PROTECTS, SILYBUM-MARIANUM, OXIDATIVE STRESS, MILK THISTLE, COMPLEMENTARY, CARBOPLATIN, EFFICACY, SKIN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objective: Neuroblastoma is the most common extracranial solid tumor in childhood. Cisplatin is widely used in pediatric malignancies. Silymarin is a polyflavonoid compound extracted from "milk thistle". Pro-inflammatory cytokines have a role in tumor growth and metastases of neuroblastoma cells. The aim of this study was to evaluate effects of silymarin alone or in combination with cisplatin on the production of antitumoral and pro-inflammatory cytokine in neuroblastoma cells.