Akademik Veri Yönetim Sistemi
SN Comprehensive Clinical Medicine, cilt.3, sa.7, ss.1645-1651, 2021 (Scopus)
Frosted branch angiitis (FBA) is a rare type of severe retinal vasculitis characterized with a widespread perivascular translucent sheathing in association with a variable degree of anterior and/or posterior segment inflammation. Secondary type of FBA is the term coined for the patients with various underlying autoimmune diseases or viral infections. We aim to describe the clinical course of a case with a unilateral frosted branch angiitis most likely associated with the hyperhomocysteinemia and methylene tetrahydrofolate reductase mutation who initially presented us with a unilateral central retinal vein occlusion-like appearance. A 37-year-old otherwise healthy woman presented with a left central retinal vein occlusion-like appearance. Extensive systemic and coagulation work up was unremarkable except for the elevated plasma homocysteine level and heterozygous methylene tetrahydrofolate reductase gene mutation. A week later, a full-blown picture of frosted branch angiitis was established. A successful visual and anatomic outcome was achieved with the pulse and then oral steroids, oral azathioprine, and multiple intravitreal aflibercept injections. Two key messages can be considered. First, central retinal vein occlusion-like presentation can be the very early phase of clinical evolution of FBA, and second, patients with FBA should also be evaluated for possible coagulation abnormalities.