Animal models for Cancer Immunology

Kum Özşengezer S., Altun Z. S.

CURRENT MOLECULAR BIOLOGY REPORTS, vol.9, no.3, pp.1-10, 2023 (Peer-Reviewed Journal)


Purpose of Review This review discusses the characteristics of different in vivo experimental immunologic models for the development of immunotherapies and the role of immunology in cancer. Recent Findings According to recent studies, different immunologic mouse models are being created using diverse strains and customized according to cancer type. Summary Cancer immunology and immunotherapy offer important therapeutic opportunities to develop new cancer treatments and improve patient survival. Unfortunately, immunotherapies do not always produce positive results. More studies, including patient-derived animal models, are needed to find new therapeutics and achieve positive immune responses against cancer. In particular, differentiated, humanized immunological mouse models, despite their limitations, facilitate the understanding of the mechanism of cancer therapeutics, the development of treatment modalities, drug administration, and the development of preclinical studies.