Overexpression of minichromosome maintenance protein 10 in medulloblastoma and its clinical implications

Senfter D., Erkan E. P., ÖZER E., Jungwirth G., Madlener S., Kool M., ...More

PEDIATRIC BLOOD & CANCER, vol.64, no.12, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 64 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1002/pbc.26670
  • Journal Name: PEDIATRIC BLOOD & CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: MCM10, medulloblastoma, minichromosome maintenance protein, prereplication complex, HIGH-DOSE CHEMOTHERAPY, MCM2-7 DOUBLE-HEXAMER, STEM-CELL RESCUE, DNA-REPLICATION, BRAIN-TUMORS, COMPLEX, INHIBITION, MUTATIONS, SUBGROUPS, SURVIVORS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Overexpression of minichromosome maintenance (MCM) proteins 2, 3, and 7 is associated with migration and invasion in medulloblastoma (MB). However, expression profiling of all prereplication complex (pre-RC) has not been addressed in MBs.