Psoriasis after Pegylated Interferon-Treatment of Chronic Hepatitis B Infection: Case Report

Akman S. A., Kose Ş., Halicioglu O., Bayol U., Alper S.

VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL, cilt.14, sa.2, ss.77-80, 2009 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2009
  • Dergi Adı: VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.77-80
  • Anahtar Kelimeler: Chronic hepatitis B, interferon, psoriasis
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

The pegylated interferon-alpha (peg IFN-alpha) is one of the treatment options for chronic hepatitis B infection in adulthood. Interferon alfa treatment is associated with considerable side effects. Most frequently reported side effects are flu-like symptoms, fatigue, headache, and myalgia and rarely immunologic and autoimmune events, and cutaneous adverse reactions may develop as well. Drug-induced cutaneous eruptions include injection site reactions, psoriasis, eczematous drug reactions, alopecia, pigmentary changes, and lichenoid eruptions. In the present study, a 19-year-old male patient who has adverse cutaneous reactions related to peg IFN-alpha has been reported. IFN-alpha treatment related lesions, such as leukocytoclastic vasculitis, were successfully treated with topical therapy. Biopsy proven psoriasis was seen eight months after completing the INF treatment.