B-RAF V600E AND B-RAF CODON 464-469 MUTATIONS IN HAIRY CELL LEUKEMIA PATIENTS AND THEIR RELATION WITH CLINICAL PARAMETERS

Olgun, Aybuke; BAŞBINAR, YASEMİN; ALACACIOĞLU, İNCİ; Solmaz, Serife; Akbarpour, Mahdi; Kilic, Tugba; Birge, Ozlem; ÖZKAL, SERMİN; ELLİDOKUZ, HÜLYA; ÖZCAN, MEHMET

doi:10.30621/jbachs.868298

B-RAF V600E AND B-RAF CODON 464-469 MUTATIONS IN HAIRY CELL LEUKEMIA PATIENTS AND THEIR RELATION WITH CLINICAL PARAMETERS

Olgun A., BAŞBINAR Y., ALACACIOĞLU İ., Solmaz S., Akbarpour M., Kilic T. U. Y. S. A. L., ...Daha Fazla

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.5, sa.3, ss.1-6, 2021 (ESCI, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 5 Sayı: 3
Basım Tarihi: 2021
Doi Numarası: 10.30621/jbachs.868298
Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.1-6
Anahtar Kelimeler: Hairy cell leukemia, B-RAF V600E, B-RAF G464E, B-RAF G469E
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder which counts %2-3 percent of the leukemias. B-RAF is a member of mitogen activated protein kinase pathway, associated with cell proliferation. The most common B-RAF mutation V600E has been shown in hairy cell leukemia recently. The aim of our study is to investigate B-RAF V600E and B-RAF codon 464-469 mutations in HCL patients and compare the results with clinical parameters.