B-RAF V600E AND B-RAF CODON 464-469 MUTATIONS IN HAIRY CELL LEUKEMIA PATIENTS AND THEIR RELATION WITH CLINICAL PARAMETERS

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Olgun A., BAŞBINAR Y., ALACACIOĞLU İ., Solmaz S., Akbarpour M., Kilic T. U. Y. S. A. L., ...Daha Fazla

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.5, sa.3, ss.1-6, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.30621/jbachs.868298
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.1-6
  • Anahtar Kelimeler: Hairy cell leukemia, B-RAF V600E, B-RAF G464E, B-RAF G469E, TERM-FOLLOW-UP, BRAF MUTATIONS, PENTOSTATIN, COMPLICATIONS, CLADRIBINE, DIAGNOSIS, VARIANT
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder which counts %2-3 percent of the leukemias. B-RAF is a member of mitogen activated protein kinase pathway, associated with cell proliferation. The most common B-RAF mutation V600E has been shown in hairy cell leukemia recently. The aim of our study is to investigate B-RAF V600E and B-RAF codon 464-469 mutations in HCL patients and compare the results with clinical parameters.