B-RAF V600E AND B-RAF CODON 464-469 MUTATIONS IN HAIRY CELL LEUKEMIA PATIENTS AND THEIR RELATION WITH CLINICAL PARAMETERS

Olgun, Aybuke; BAŞBINAR, YASEMİN; ALACACIOĞLU, İNCİ; Solmaz, Serife; Akbarpour, Mahdi; Kilic, Tugba; Birge, Ozlem; ÖZKAL, SERMİN; ELLİDOKUZ, HÜLYA; ÖZCAN, MEHMET

doi:10.30621/jbachs.868298

B-RAF V600E AND B-RAF CODON 464-469 MUTATIONS IN HAIRY CELL LEUKEMIA PATIENTS AND THEIR RELATION WITH CLINICAL PARAMETERS

Olgun A., BAŞBINAR Y., ALACACIOĞLU İ., Solmaz S., Akbarpour M., Kilic T. U. Y. S. A. L., ...More

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.5, no.3, pp.1-6, 2021 (ESCI, TRDizin)

Publication Type: Article / Article
Volume: 5 Issue: 3
Publication Date: 2021
Doi Number: 10.30621/jbachs.868298
Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
Page Numbers: pp.1-6
Keywords: Hairy cell leukemia, B-RAF V600E, B-RAF G464E, B-RAF G469E
Open Archive Collection: AVESIS Open Access Collection
Dokuz Eylül University Affiliated: Yes

Abstract

Purpose: Hairy cell leukemia (HCL) is a chronic lymphoproliferative disorder which counts %2-3 percent of the leukemias. B-RAF is a member of mitogen activated protein kinase pathway, associated with cell proliferation. The most common B-RAF mutation V600E has been shown in hairy cell leukemia recently. The aim of our study is to investigate B-RAF V600E and B-RAF codon 464-469 mutations in HCL patients and compare the results with clinical parameters.