Effects of Lipoic Acid in an Experimentally Induced Hypertensive and Diabetic Rat Model

CİLAKER MIÇILI S., Ergur B. U., ÖZOĞUL C., SARIOĞLU S., BAĞRIYANIK H. A., TUĞYAN K., ...More

CLINICAL AND EXPERIMENTAL HYPERTENSION, vol.35, no.5, pp.373-381, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.3109/10641963.2012.732647
  • Journal Name: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.373-381
  • Keywords: kidney, nephrectomy, diabetes mellitus, ultrastructure, histology, OXIDATIVE STRESS, GLOMERULAR SIZE, KIDNEY, DAMAGE, ANTIOXIDANT, MECHANISMS, EXPRESSION, APOPTOSIS, INSULIN, TISSUE
  • Dokuz Eylül University Affiliated: Yes

Abstract

In this study, experimental diabetes and nephrectomy have been applied separately and together in order to investigate the possible therapeutic effects of lipoic acid (LA) on hypertensive and diabetic rat kidneys. Wistar rats were divided into eight groups: control, diabetes mellitus (DM), 5/6 nephrectomy, DM + 5/6 nephrectomy, LA administration, DM + LA treated, 5/6 nephrectomy + LA treated, and DM + 5/6 nephrectomy + LA-treated groups, respectively. Renal damage was evaluated histomorphometrically, ultrastructurally, and biochemically. Our findings supported that diabetes and hypertension together increased the rate of renal injury, and LA had therapeutic effects on hypertensive and diabetic rat kidneys.