Interactome of Obesity: Obesidome Genetic Obesity, Stress Induced Obesity, Pathogenic Obesity Interaction

Geronikolou S. A., PAVLOPOULOU A., Cokkinos D., Chrousos G.

GENEDIS 2016: GENETICS AND NEURODEGENERATION, cilt.987, ss.233-241, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 987
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/978-3-319-57379-3_21
  • Dergi Adı: GENEDIS 2016: GENETICS AND NEURODEGENERATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.233-241
  • Anahtar Kelimeler: Interactome, Obesidome, Genetic obesity, Autonomic nervous system, Inflammation, Stress induced obesity, Pathogenic obesity, PITUITARY-ADRENAL AXIS, ASSOCIATION, VARIANTS, GHRELIN, RISK
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Obesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g. MC4R defects)-environment (behavior, infectious agents, stress) interactions is a relative new field of great research interest. In this study, we have made an effort to create an interactome (henceforth referred to as "obesidome"), where extrinsic stressors response, intrinsic predisposition, immunity response to inflammation and autonomous nervous system implications are integrated. These pathways are presented in one interactome network for the first time. In our study, obesity-related genes/gene products were found to form a complex interactions network.