ORGANOID AS A NOVEL TECHNOLOGY FOR DISEASE MODELING

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Sever T., Cevik I., Calibasi-Kocal G., BAŞBINAR Y., ELLİDOKUZ E. B.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.5, sa.1, ss.94-101, 2021 (ESCI, TRDizin)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 5 Sayı: 1
• Basım Tarihi: 2021
• Doi Numarası: 10.30621/jbachs.868837
• Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.94-101
• Anahtar Kelimeler: Organoid, Disease Modeling, Stem Cell
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The organoid technology is capable to create more real-like in vitro models in terms of structure and function of the origin of the tissue. Since the three-dimensional model is able to illustrate disease pathology, cell differentiation, and recapitulation of self-renewal, lead organoid technology as a promising disease model to fill the gap between conventional two-dimensional, and in vivo disease models. The review describes the recent development of organoid disease modeling approaches.