INVESTIGATION OF THE ANTI-TUMOR EFFECTS OF BEVACIZUMAB ON GLIOBLASTOMA CELLS

Hasimoglu Z., ERBAYRAKTAR Z., ERBAYRAKTAR R. S.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, vol.5, no.2, pp.110-114, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.30621/jbachs.934220
  • Journal Name: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.110-114
  • Keywords: Brain tumors, glioblastoma, bevacizumab, apoptosis, drug resistance, NEWLY-DIAGNOSED GLIOBLASTOMA, RANDOMIZED PHASE-III, TEMOZOLOMIDE, RADIOTHERAPY, ANGIOGENESIS, RESISTANCE, TRIAL
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: Glioblastoma multiforme (GBM) is the most malignant glial tumor. Angiogenesis which provides nutrient and oxygen support to proliferating cells plays an essential role in GBM development, proliferation, and metastasis. The development of antiangiogenetic agents is a promising treatment approach as blood vessels are essential for the vitality of tumor cells. For this purpose, in this study, the effects of bevacizumab on cell viability and apoptosis were analyzed using glioblastoma cells.