Cingulate biochemistry in heroin users on substitution pharmacotherapy

Verdejo-Garcia A., Lubman D. I., Roffel K., Vilar-Lopez R., BORA İ. E., MacKenzie T., ...Daha Fazla

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, cilt.47, sa.3, ss.244-249, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1177/0004867412463088
  • Dergi Adı: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.244-249
  • Anahtar Kelimeler: Dorsal anterior cingulate cortex, methadone, buprenorphine, depression, myo-inositol, glutamate, CHRONIC MORPHINE TREATMENT, DEPENDENT INDIVIDUALS, METHADONE-MAINTENANCE, PREFRONTAL CORTEX, OPIATE DEPENDENCE, BUPRENORPHINE, METAANALYSIS, VOLUNTEERS, DEPRESSION, ADDICTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objective: High doses of opiate substitution pharmacotherapy are associated with greater treatment retention and lower illicit drug consumption, although the neurobiological bases of these benefits are poorly understood. Dysfunction of the anterior cingulate cortex (ACC) is associated with greater addiction severity and mood dysregulation in opiate users, such that the beneficial effects of substitution pharmacotherapy may relate to normalisation of ACC function. This study aimed to investigate the differential impact of methadone compared with buprenorphine on dorsal ACC biochemistry.A secondary aim was to explore the differential effects of methadone and buprenorphine on dorsal ACC biochemistry in relation to depressive symptoms.