Cingulate biochemistry in heroin users on substitution pharmacotherapy
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, vol.47, no.3, pp.244-249, 2013 (SCI-Expanded, SSCI, Scopus)
- Publication Type: Article / Article
- Volume: 47 Issue: 3
- Publication Date: 2013
- Doi Number: 10.1177/0004867412463088
- Journal Name: AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
- Page Numbers: pp.244-249
- Keywords: Dorsal anterior cingulate cortex, methadone, buprenorphine, depression, myo-inositol, glutamate
- Dokuz Eylül University Affiliated: Yes
Abstract
Objective: High doses of opiate substitution pharmacotherapy are associated with greater treatment retention and lower illicit drug consumption, although the neurobiological bases of these benefits are poorly understood. Dysfunction of the anterior cingulate cortex (ACC) is associated with greater addiction severity and mood dysregulation in opiate users, such that the beneficial effects of substitution pharmacotherapy may relate to normalisation of ACC function. This study aimed to investigate the differential impact of methadone compared with buprenorphine on dorsal ACC biochemistry.A secondary aim was to explore the differential effects of methadone and buprenorphine on dorsal ACC biochemistry in relation to depressive symptoms.