Casticin: A Promising Candidate to Develop a Stem Cell Targeted Strategy in AML Treatment

Erkmen T., Serdar B. S., Ateş H., Keskinoğlu P., Kocturk S.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.3, ss.297-304, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30621/jbachs.2020.1226
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.297-304
  • Anahtar Kelimeler: apoptosis, acute myeloid leukemia, Casticin, cancer stem cells, ACUTE MYELOID-LEUKEMIA, APOPTOSIS, NECROPTOSIS, EXPRESSION, DEATH
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Acute myeloid leukemia is the most common form of acute leukemia with genetic and epigenetic heterogeneity. Although current therapeutic agents provide successful remission, 5-year survival rates are still low. Insufficiency of targeting leukemia stem cells is considered as the main obstacle that causes drug resistance and relapse. Phytochemicals remain a promising source for targeted drug research. Studies showed that Casticin has antiproliferative effects on leukemic cells, but its effects on leukemic stem cells are still unclear. In this study, we aimed to investigate the antiproliferative capacity of Casticin on acute myeloid leukemia stem-like (KG1a) cells and its relatively mature parental (KG1) cells in comparison with healthy peripheral blood mononuclear cells (PBMC).