Synthesis of Murrayaquinone-A Derivatives and Investigation of Potential Anticancer Properties

Cagatay E., AKYILDIZ V., Ergun Y., AYAR KAYALI H.

CHEMISTRY & BIODIVERSITY, vol.18, no.11, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 11
  • Publication Date: 2021
  • Doi Number: 10.1002/cbdv.202100348
  • Journal Name: CHEMISTRY & BIODIVERSITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: murrayaquinone A, organic synthesis, anti-tumor activity, colon cancer cell lines, CELL-CYCLE ARREST, HYDROGEN-PEROXIDE, OXIDATIVE STRESS, SERUM-ALBUMIN, APOPTOSIS, CANCER, BINDING, DEATH, CARBAZOLEQUINONES, CYTOTOXICITY
  • Dokuz Eylül University Affiliated: Yes

Abstract

A series of novel murrayaquinone a derivatives were synthesized and their anti-cancer activity were evaluated on healthy colon cell lines (CCD-18Co), primary (Caco-2) and metastatic (DLD-1) colon cancer cell lines. The results showed that the cytotoxicity of murrayaquinone molecules is significantly high even in micromolar levels. The DNA binding, cell cycle arrest and metabolic activity studies of these molecules were also carried out and the results showed that these molecules induce apoptosis. In conclusion, the data support further studies on murrayaquinone derivatives toward selection of a candidate for cancer treatment.