Role of quantitative hepatitis B surface antigen levels in predicting liver biopsy time in treatment-naive chronic hepatitis B patients

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Tatar B., Acar A., Adar P., Kose Ş.

CLINICAL AND EXPERIMENTAL HEPATOLOGY, cilt.6, sa.1, ss.55-59, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5114/ceh.2020.93058
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HEPATOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.55-59
  • Anahtar Kelimeler: chronic hepatitis B, quantitative hepatitis B surface antigen, liver biopsy, hepatocytes, NATURAL-HISTORY, VIRUS, HBSAG
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Aim of the study: The quantitative hepatitis B surface antigen (qHBsAg) level indicates the amount of transcriptional activity of covalently closed circular DNA (cccDNA) and integrated DNA in hepatocytes which plays a role in development of chronic hepatitis B (CHB) and may help decide whether the treatment is necessary or not. The aim of this study is to evaluate the association between serum qHBsAg levels and viral replication and stage of liver fibrosis in treatment-naive CHB patients and to determine the role of qHBsAg levels in predicting when liver biopsy is necessary.