Allopurinol in rat chronic pancreatitis - Effects on pancreatic stellate cell activation

Tasci I., Deveci S., IŞIK A. T., Comert B., Akay C., Mas N. N., ...More

PANCREAS, vol.35, no.4, pp.366-371, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2007
  • Doi Number: 10.1097/mpa.0b013e31806dbaaa
  • Journal Name: PANCREAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.366-371
  • Keywords: chronic pancreatitis, pancreatic stellate cells, oxidative stress, xanthine oxidase, allopurinol, alpha smooth muscle actin, NITRIC-OXIDE, FREE-RADICALS, SUPEROXIDE-DISMUTASE, REPERFUSION INJURY, URIC-ACID, FIBROSIS, DYSFUNCTION, IDENTIFICATION, FIBROGENESIS, EXPRESSION
  • Dokuz Eylül University Affiliated: No

Abstract

Objectives: Activation of pancreatic stellate cells (PSCs) is a key event in pancreatic fibrosis. Xanthine oxidase-derived free radicals are involved in the mechanism of chronic pancreatitis (CP). We here searched the in vivo effects of allopurinol on PSC activation and its relation to tissue oxidative stress and histological findings in rat CP.