Allopurinol in rat chronic pancreatitis - Effects on pancreatic stellate cell activation

Tasci I., Deveci S., IŞIK A. T., Comert B., Akay C., Mas N. N., ...Daha Fazla

PANCREAS, cilt.35, sa.4, ss.366-371, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1097/mpa.0b013e31806dbaaa
  • Dergi Adı: PANCREAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.366-371
  • Anahtar Kelimeler: chronic pancreatitis, pancreatic stellate cells, oxidative stress, xanthine oxidase, allopurinol, alpha smooth muscle actin, NITRIC-OXIDE, FREE-RADICALS, SUPEROXIDE-DISMUTASE, REPERFUSION INJURY, URIC-ACID, FIBROSIS, DYSFUNCTION, IDENTIFICATION, FIBROGENESIS, EXPRESSION
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Objectives: Activation of pancreatic stellate cells (PSCs) is a key event in pancreatic fibrosis. Xanthine oxidase-derived free radicals are involved in the mechanism of chronic pancreatitis (CP). We here searched the in vivo effects of allopurinol on PSC activation and its relation to tissue oxidative stress and histological findings in rat CP.