Subclinical Hypercortisolism among Polycythemia Vera Patients

Bilgir O., Kebapcilar L., Alacacioglu I., Bilgir F., Yildiz Y., Yuksel A., ...Daha Fazla

INTERNAL MEDICINE, cilt.49, sa.13, ss.1277-1280, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 13
  • Basım Tarihi: 2010
  • Doi Numarası: 10.2169/internalmedicine.49.2763
  • Dergi Adı: INTERNAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1277-1280
  • Anahtar Kelimeler: polycythemia vera, subclinical hypercortisolism, JAK, PRECLINICAL CUSHINGS-SYNDROME, ADRENAL INCIDENTALOMAS, ESSENTIAL THROMBOCYTHEMIA, DIFFERENTIAL-DIAGNOSIS, CONSENSUS STATEMENT, JAK2 MUTATION, CELL-LINE, CRITERIA, PATHWAY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background JAK2V617F, a somatic gain-of-function mutation involving the JAK2 tyrosine kinase gene, occurs in nearly all patients with polycythemia vera (PV). JAK2 is also essential in hypothalamo-pituitary-adrenal (HPA) axis system which is known to play a role in subsequent steroid secretion. The purpose of this study was to determine whether or not PV induces subclinical hypercortisolism (SH).