Changing nodule activity with time on Tc-99m pertechnetate thyroid scintigraphy

Ozdogan Ö., Imren Y., Topcu I., Gurel D., Vayvada H., Durak H.

CLINICAL NUCLEAR MEDICINE, vol.31, no.3, pp.168-169, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 31 Issue: 3
  • Publication Date: 2006
  • Doi Number: 10.1097/01.rlu.0000200732.79444.df
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.168-169
  • Keywords: thyroid nodule, Tc-99m pertechnetate, I-131, I-123
  • Dokuz Eylül University Affiliated: Yes


A patient with a diagnosis of malignant melanoma was found to have a multinodular goiter on routine examination. Thyroid function tests revealed normal free T4 and TSH levels. A multinodular goiter was confirmed by thyroid ultrasonography with the dominant nodule located at the isthmus. Tc-99m pertechnetate thyroid scintigraphy did not reveal nodule activity. Delayed imaging was performed for localization of the dominant nodule with a marker. Surprisingly, the nodule was found to be hyperactive. The nodule was normoactive on I-131 thyroid scintigraphy. Fine needle aspiration biopsy confirmed a colloid nodule with follicular epithelial cells.