Mechanical properties and biocompatibility of the sputtered Ti doped hydroxyapatite

Vladescu A., Padmanabhan S. C., AK AZEM N. F., Braic M., Titorencu I., Birlik I., ...Daha Fazla

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, cilt.63, ss.314-325, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jmbbm.2016.06.025
  • Dergi Adı: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.314-325
  • Anahtar Kelimeler: Magnetron sputtering, Hydroxyapatite, Biomaterial, Cell viability, Roughness, DNA, SURFACE MODIFICATION, NANOINDENTATION, DEPOSITION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

The hydroxyapatite enriched with Ti were prepared as possible candidates for biomedical applications especially for implantable devices that are in direct contact to the bone. The hydroxyapatites with different Ti content were prepared by RF magnetron sputtering on Ti-6Al-4V alloy using pure hydroxyapatite and TiO2 targets. The content of Ti was modified by changing the RF power fed on TiO2 target. The XPS and FTIR analyses revealed the presence of hydroxyapatite structure. The hardness and elastic modulus of the hydroxyapatite were increased by Ti addition. After 5 days of culture, the cell viability of the Ti-6Al-4V was enhanced by depositing with undoped or doped hydroxyapatite. The Ti additions led to an increase in cell viability of hydroxyapatite, after 5 days of culture. The electron microscopy showed the presence of more cells on the surface of Ti-enriched hydroxyapatite than those observed on the surface of the uncoated alloys or undoped hydroxyapatite. (C) 2016 Elsevier Ltd. All rights reserved.