Akademik Veri Yönetim Sistemi
26th Annual Conference of the European Society for Clinical Virology, Frankfurt, Almanya, 18 - 21 Eylül 2024, ss.127-128, (Özet Bildiri)
AIM: This study aimed to evaluate clinical and microbiological characteristics of enterovirus (EV)
infections in children with acute respiratory infections in a university hospital in Izmir, Turkey
METHODS: Between March 2022 and November 2023, 640 respiratory samples of patients with acute respiratory
infections were tested with syndromic respiratory panels (Bio-Speedy respiratory tract RT-qPCR MX-24, Bio-
Speedy Respiratory ID-2 kit, QIAstat-Dx respiratory SARS-CoV-2 panel). Rhinovirus/enterovirus positive samples
were re-tested with a specific in-house RT-qPCR assay to confirm the presence of enterovirus. Demographic
and clinical characteristics, comorbidities, coinfections were analyzed.
RESULTS: Of the 640 samples, 376 (58%) were positive for one or more respiratory pathogens; 219 of which
were positive for rhino/enterovirus. 157 samples were retested with EV-specific RT-qPCR and 29 (18.4%) were
confirmed as EV. Among the EV+ patients, 21 (72%) were ≤5 years old (mean: 3.80 years; 1 month-15 years), 10
(34%) had underlying medical condition, 6 of whom had asthma or reactive airway disease. Most EV+ children
(86%) required hospitalization, 51% were treated for bronchospasm, 4 received respiratory support. Coinfection
was detected in 7 EV+ patients (24%) and the second most common agent was adenovirus. None of the EV+
patients had positive bacterial cultures in respiratory samples. EV sequencing studies are continuing.
CONCLUSIONS: Among pediatric patients admitted to hospital with acute respiratory tract infection, EV
positivity was more common in children under 5 years of age, and most of these cases required inpatient care,
half of which were treated for bronchospasm.
SOURCES OF FUNDING: None